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Best Elaborated Achievement of Circulatory Homeostasis


The main focus of the working group is to create algorithms to guide volume, fluid and catecholamine therapy and to evaluate their clinical impact on perioperative care of our patients. The relevance for the surgical patient of preload optimization using the oesophageal Doppler is shown in several studies. The oesophageal Doppler represents a minimal-invasive method to monitor hemodynamic parameters and was used within a targeted-volume protocol, which led to reduced length of stay and decreased morbidity.


The standardization of the mean arterial pressure and cardiac index and the integration with preload optimization into a clinical algorithm is the next step to achieve circulatory homeostasis. The impact of the algorithm on outcome and the perioperative course of the patient is one of the main goals of the working group by randomized controlled studies. A special focus is to investigate the influence of the goal-directed hemodynamic therapy on delirium and the cognitive function of the patients as these factors are key elements to influence quality of life after a surgical procedure.


The standardized goal-directed algorithm offers the possibility to investigate the effects of crystalloid and colloid solutions for volume replacement in perioperative patients. The aim of the perioperative volume therapy is the maintenance or recovery of the intravascular normovolemia without expansion of the interstitial space. Crystalloids stay only for ¼ intravascular and expand the interstitial space. On the other hand during normovolemia or slight hypovolemia starch solutions have an intravascular volume effect of 100 % without expansion of the interstitial space and without causing edema. There are hints of different organ dysfunctions after either of these fluids. On one hand current evidence indicates that using crystalloids exclusively may cause overloading of the interstitial compartment with considerable negative sequelae, whereas using colloids may improve microperfusion and tissue oxygenation. On the other hand colloids have a potential to reduce renal function if overdosed. The role is unclear in hypovolemic and hypervolemic states. In particular, "dry" states can occur in orthopedic hip surgery, often seen in elderly patients. 

Actual Studies inscribed in ISRCTN or

  • The effect of an intraoperative, goal-directed volume protocol in abdominal surgery within an accelerated recovery program after surgery (Enhanced Recovery Program After Surgery: ERAS-Program)
  • Balanced crystalloids versus balanced colloids within a goal-directed haemodynamic protocol in patients undergoing gynaecological tumour resection: a prospective, randomised, controlled, double-blinded, two-armed single centre trial
  • Intraoperative comparision of a goal-directed hemodynamic protocol by monitoring with LiDCOrapid or osophageal Doppler and conventional therapy during liver resection – a pilot study
  • Clinical Monitoring of Endothelial Dysfunction for Pregnant Women and in the Perioperative Course - a Pilot Study

International Anaesthesiological Cooperations within the ERAS ® (Enhanced recovery after surgery) group

  • Dr. P.B.W. Cox (Department of Anesthesiology and Pain therapy), University Hospital Maastricht (azM), The Netherlands
  • Dr. Franco Carli and Dr. Gabriele Baldini, Department of Anesthesia, McGill University Health Centre, Montreal, Quebec, Canada
  • Dr. Tomas Ruiz Garces and Dr. Rubén Casans Francés (Anestesiología y Reanimación) Hospital Clínico Lozano Blesa, Universidad de Zaragoza, Spain

International Interdisciplinary Cooperations: Spanish Working Group on Fast-Track Surgery

  • Prof. Dr. Jose Manuel Ramirez Rodriguez, Department of Surgery, University Hospital of Zaragoza, Spain

Ovarian Cancer Outcome after Surgery

  • Prof. Dr. Christina Fotopoulou, Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, United Kingdom

Interdisciplinary Cooperations within the Charité

  • Prof. Dr. P. Neuhaus, PD Dr. Martin Stockmann, Klinik für Allgemein-, Visceral- und Transplantationschirurgie, Charité Campus Virchow-Klinikum
  • Prof. Dr. J. Sehouli, Dr. Elena-Ioana Braicu, Department of Gynaecology, European Competence Center for Ovarian Cancer, Campus Virchow-Klinikum
  • PD Dr. med. A. Weimann, Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Campus Virchow-Klinikum


Chief of staff:

Claudia Spies

Staff members:

Beutlhauser, Torsten


Boemke, Willehad


Feldheiser, Aarne


Hunsicker, Oliver


Kaufner, Lutz


Koch, Mandy


Krebbel, Holger


Müller, Olga


Pavlova, Velizara


Rosin, Adrian


Sander, Michael


Treskatsch, Sascha


Von Heymann, Christian


Weimann, Karin